Magic with rapamycin

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Pre-treatment with rapamycin protects hematopoiesis against radiation injury

Background: Protection of hematopoietic system has become a primary goal in the development of novel medical countermeasures against ionization radiation and radiotherapy. This study was to explore the role of rapamycin in normal tissues against radiation. Materials and Methods: Mice were pretreated with rapamycin by i.p. every other day for five times before 5 Gy or 8.5 Gy γ-ray whole bo...

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Purpose of the Study Pulmonary metastasis continues to be the major cause of mortality among human and canine patients with osteosarcoma. A series of investigational agents will be evaluated in dogs with appendicular osteosarcoma with the hopes of identifying new drugs that help dogs live longer after being diagnosed with osteosarcoma. Rapamycin is a drug that may help slow down the progression...

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ژورنال

عنوان ژورنال: Nature Reviews Neuroscience

سال: 2008

ISSN: 1471-003X,1471-0048

DOI: 10.1038/nrn2467